Wuhan Pharma Chemical Co., Ltd.

Model Number: PT-141 Brand Name: Biopharm Key Specifications/Special Features: Lyophilized peptide for bodybuilding bremelanotide PT-141Description:PT-141 (Bremelanotide) is a highly potent synthetic peptide analogue of α-MSH that may elicit effects through stimulation of melanocortin receptorsPT-141 (Bremelanotide) consists of seven amino acids and is a cyclic, shortened lactam variant of alpha-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of physiological functionsIn studies, bremelanotide was shown to induce lordosis in an animal model and was also effective in treating in both men (erectile dysfunction or impotence) and women (arousal disorder)

1. Specifications:
   Name: PT-141
   Synonyms: bremelanotide, PT-141 acetate
   CAS #: 189691-06-3
   Molecular formula: C50H68N14O10
   Molecular mass: 1025.2 Da (g/mol)
   Amino acid sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
   Molecular structure:
   
   

1. Purity
   PT-141 has peptide purity level that exceeds 99.0% as determined by HPLC and MS
2. This peptide was synthesized with no additives and is supplied as white lyophilized (freeze-dried) powder
3. Bremelanotide, similarly to its analogues α-MSH and melanotan II, acts as a non-selective agonist of all of the melanocortin receptors except MC2, where it lacks significant affinity
4. Reported activity of the drug is as follows:
   MC1 (Ki = 0.68 nM)
   MC2 (Ki > 1000 nM)
   MC3 (Ki = 72.07 nM)
   MC4 (Ki = 19.25 nM)
   MC5 (Ki = 166.8 nM)
   
   Bremelanotide appears to stimulate desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved)
5. Modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors
   
   According to Palatin Technologies' original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats
6. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold
7. They concluded that bremelanotide would be more tolerable than melanotan II
8. Important: we supply this item only for research purpose